Bryson finished his first season at OTE losing in the Championship to the City Reapers. He was voted Second Team All-OTE. He averaged 14.3 points, 5.1 rebounds and 4.6 assists per game through the regular season. Scored in double figures in 12 games during the season and scored over 20 points three times. Bryson scored double figures every game until getting injured early in a game on January 14. Averaged 14.0 points and 5.2 rebounds per game in the playoffs. Scored in double figures in four of the six playoff games and posted 20 points in two of the six. In the Championship, Bryson hit a game-tying three pointer with two seconds remaining in game two before Amen hit a buzzer beater to give the Reapers a 2-0 lead.
Bryson helped lead his team to a championship in the first season of Overtime Elite by being one of the most consistent scorers in the league. He scored in double figures in 18 games, and was sixth in the league in three-point percentage. He made at least one three in 22 games and had at least one assist in 24 games. Bryson hit the first game winner in league history on opening night in overtime against Vertical Academy. This summer he practiced with Team USA for their mini camp in New Orleans during the 2022 Final Four, and took part at the Team USA tryout in Colorado Springs. He also led his team to a championship and was named to the All-Tournament team at the Top 100 NBPA Camp with Matt and Ryan Bewley.
Warren became the first sophomore in Arkansas history to be named Player of the Year after averaging 24.1 PPG, 3.5 RPG, 3.7 APG and 2.5 SPG per game at Little Rock Central.